![]() ![]() Decompressive surgery results in spinal instability in humans however, the effects of decompressive surgery in either NCD or CD dogs separately have not been investigated. The aim of surgery for IVD degeneration-related diseases is to relieve the compression of neural structures and may consist of removal of the NP (nucleotomy) alone or combined with partial removal of the vertebral roof (laminectomy). Moreover, significant differences in the cell population (NCD: rich in notochordal cells CD: rich in chondrocyte-like cells), matrix composition, and morphology of the nucleus pulposus (NP) can be seen at an early age in the two types of dog. In contrast, in NCD dogs, signs of IVD degeneration are generally seen later in life, at 6–8 years of age. CD dogs develop IVD degeneration at about 1 year of age. The CD dogs are characterized by abnormal growth of the long bones due to a genetic disorder, resulting in short limbs relative to the length of the spine, whereas the NCD dogs exhibit a normal growth of the long bones. ![]()
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